An orthopedic brace may include a main panel made of a flexible, breathable elastic fabric, such as perforated neoprene or AIRPRENE.® The main body panel includes a a fastening implement, such as hook-and-loop fasteners to secure the main body panel in an encircling position on or near a subject area of the human body. The brace may a shank embedded in the main panel to add rigidity in one or more areas. At least two adjustable strap loops may cooperate with the shank to provide targeted and precise compressive forces to the treatment area when the brace is installed. The strap loops may be anchored at one end to the main panel, extend through sliding rings and may be provided with fasteners at another end to adjustably engage corresponding fastening pads on the main body panel. The adjustable strap loops, rings and shank cooperate to provide for the targeted and precise application and distribution of pressure force to the treatment area.