BRETT ULLMAN,JASON B. IBARRA,NING ZOU,THUY-ANH TRAN,XI ZENG,YOUNG-JUN SHIN,ULLMAN BRETT,IBARRA JASON B,ZOU NING,TRAN THUY-ANH,ZENG XI,SHIN YOUNG-JUN
申请号：
BRPI0921369
公开号：
BRPI0921369A2
申请日:
2009.11.24
申请国别(地区):
BR
年份:
2015
代理人:
摘要：
Pyrazole derivatives of Formula la and pharmaceutical compositions thereof that modulate the activity of the PGI2 receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of: pulmonary arterial hypertension (PAH) and related disorders； platelet aggregation； coronary artery disease； myocardial infarction； transient ischemic attack； angina； stroke； ischemia-reperfusion injury； restenosis； atrial fibrillation； blood clot formation in an angioplasty or coronary bypass surgery individual or in an individual suffering from atrial fibrillation； atherosclerosis； atherothrombosis； asthma or a symptom thereof； a diabetic-related disorder such as diabetic peripheral neuropathy, diabetic nephropathy or diabetic retinopathy； glaucoma or other disease of the eye with abnormal intraocular pressure； hypertension； inflammation； psoriasis； psoriatic arthritis； rheumatoid arthritis； Crohn's disease； transplant rejection； multiple sclerosis； systemic lupus erythematosus (SLE)； ulcerative colitis； ischemia-reperfusion injury； restenosis； atherosclerosis； acne； type 1 diabetes； type 2 diabetes； sepsis； and chronic obstructive pulmonary disorder (COPD).
