Pharmaceutical compositions for reducing frequency of urination are disclosed. The pharmaceutical compositions comprise one or more analgesic agents and a PDE5 inhibitor. Also disclosed are methods of making and using of the pharmaceutical compositions.本發明揭示用於降低排尿頻率之醫藥組成物。該醫藥組成物係包含一或多種止痛劑及一PDE5抑制劑。本發明亦揭示製造或使用該醫藥組成物的方法。