The present invention discloses a construction process of biocompatible micro-nano material which can be used for drug loading and sustained release. The constructed biomaterial is a polyacrylate-based microbubble and nanoparticle containing genipin crosslinked chitosan using the adriamycin as model drug, the drug loading and release properties are investigated. The micro-nanoparticle material constructed by this method has improved the encapsulation efficiency and loading rate of the drug to a certain extent, which can control the in vitro release rate of the drug appropriately. The preparation process herein is simple, environmentally-friendly, free of contamination of three wastes and radiation and noises, with mild condition and low energy consumption, therefore, it is a universal process of highly biocompatible cross-linking of micro-nanoparticles.
