WHITE, KATY,TEALL, MARTIN,MACK, STEPHEN,LIWICKI, GEMMA,GOLDBY, ANNE
申请号：
ARP170100186
公开号：
AR107426A1
申请日:
2017.01.25
申请国别(地区):
AR
年份:
2018
代理人:
摘要：
Processes for their preparation, Pharmaceutical compositions containing them and their use in therapy of Hearing Disorders and CNS.Claim 1: a compound of formula (1) where r u00b9 represents hydroxyl, ch u2082oh so u2082r u00b9 u1d43 -, cyano -, - (ch u2082) u2098 - (OR) - or ( u2099 r u2075 ch u2082) u209anr u2076r u2077； M is 0 OR 1； n is 0 OR 1； and P is 0 OR 1； r u00b9 u1d43 represents alkyl c u2081 u208b u2086,C u2083 u208b u2086 cycloalkyl or cicloalquilmetilo c u2083 u208b u2086； each of R u00b2 independently and r u00b3 represents Hydrogen, halogen, fluorometilo, difluorometilo, trifluoromethyl, methoxy, fluoromethoxy,Any r u2074 u1d43 Difluoromethoxy or trifluoromethoxy； (X) represents u209c (ch u2082) - - - - u1d5b r u00b9 u2076 or ch u2082o r u00b9 u2077 and r u2074 u1d47 represents Hydrogen, Methyl or Fluorine, or r u2074 u1d43 and r u2074 u1d47, together with the carbon Atom to which it is coupled.Form a Heterocyclic Ring or carboc u00edclico saturated 3 to 6 members, where the Heterocyclic Ring comprises at least one ring Atom is selected Atoms of nitrogen and OxygenWhere the carboc u00edclico or Heterocyclic ring is not replaced or substituted with at least one Halogen Substituent is selected, c u2081 u208b u2083 oxo alkyl, alkoxy, amino, amino, c u2081 u208b u2083,Dimethylamino and haloalquilo c u2081 u208b u2083 represents a cycloalkyl Group； r u2075 c u2083 u208b u2086,A Heterocyclic Ring of 4 to 6 members, which contains an annular single hetero Atom is an atom of nitrogen Heterocyclic Ring which is not replaced or substituted with at least oneSubstituent selected from Halogen, alkyl c u2081 u208b u2083 and haloalquilo c u2081 u208b u2083 or an alkyl group c u2081 u208b u2086 is not replaced or substituted with at least one Substituent selected from c u2083 u208b u2086 cycloalkyl,Nr u00b2 u00b2r u00b2 u00b3 saturated Heterocyclic ring and a 4 to 6 Member comprising at least one ring Atom is selected Atoms of nitrogen and OxygenWhere the Hetero
