Reedtz-Runge, Steffen,Sauerberg, Per,Kofoed, Jacob,Pettersson, Ingrid,Tornoe, Christian Wenzel
申请号：
AU2014283221
公开号：
AU2014283221A1
申请日:
2014.06.19
申请国别(地区):
AU
年份:
2015
代理人:
摘要：
The invention relates to a derivative of a GLP-1 analogue, optionally C-terminally extended, which derivative comprises a first and a second protracting moiety in the form of a C20 or C22 diacid radical, a bis-amino branched linker, and a first and a second further linker each comprising an OEG-like linker element； wherein these elements are interconnected via amide bonds and attached to a Lys residue of the GLP-1 analogue. The invention also relates to intermediate products in the form of novel GLP-1 analogues incorporated in the derivatives of the invention, as well as pharmaceutical compositions and medical uses of the derivatives. The derivatives have very long half-lives while maintaining a satisfactory potency, which makes them potentially suitable for once-monthly administration.
