Carlos Perez-Medina,Thomas Reiner,Jason S. Lewis,Willem J.M. Mulder,Zahi A. Fayad
申请号：
US14722425
公开号：
US20150343100A1
申请日:
2015.05.27
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Described herein is a non-invasive quantitative positron emission tomography (PET) nanoreporter technology that allows personalized therapeutic outcome prediction. In a breast cancer mouse model, it was demonstrated that co-injecting Doxil and a Zirconium-89 nanoreporter (89Zr-NRep) enabled highly precise doxorubicin (DOX) quantification. Imaging 89Zr-NRep via PET revealed remarkable Doxil accumulation heterogeneity independent of tumor size.
