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Trisubstituted amine compounds as inhibitors of CETP cholesteryl ester transfer protein
专利权人:
MITSUBISHI TANABE PHARMA CORPORATION
发明人:
NAKAMURA, YOSHINORI,HAYASHI, NORIMITSU,HIGASHIJIMA, TAKANORI,KUBOTA, HITOSHI,OKA, KOZO
申请号:
ES07707991
公开号:
ES2381042T3
申请日:
2007.01.30
申请国别(地区):
ES
年份:
2012
代理人:
摘要:
A compound of formula (I-B): ** Formula ** where ZA is N or CH; A21A is an alkoxy group optionally substituted by 1 to 2 groups selected from a carboxyl group, a halogen atom, an alkoxycarbonyl group, an alkoxy group, a hydroxy group, a mono- or dialkylamino group, an alkylsulfinyl group, a cyano group, a tetrazolyl group, an alkylsulfonyl group and an alkylsulfanyl group; an alkyl group optionally substituted by 1 to 2 groups selected from a carboxyl group, a halogen atom, an alkoxycarbonyl group, an alkoxy group, a hydroxy group, a mono- or dialkylamino group, an alkylsulfinyl group, a cyano group, a group tetrazolyl, an alkylsulfonyl group and an alkylsulfanyl group; a morpholinyl group; a carboxyl group; or a carboxypiperidinyl group; R1A is a cyano group or an alkyl group optionally substituted by 1 to 3 halogen atoms; B 'is a group independently selected from a halogen atom, an alkyl group optionally substituted by 1 to 3 halogen atoms or an alkoxy group optionally substituted by 1 to 3 halogen atoms; pA is an integer from 0 to 3; D is a pyrimidinyl group, a pyridyl group, a phenyl group, a pyrimidinyloxy group, a tetrazolyl group or an oxazolidinyl group; D 'is a group independently selected from an alkoxy group optionally substituted by 1 to 3 halogen atoms, a halogen atom, a cyano group, an alkylsulfanyl group, a mono- or dialkylamino group, an alkenyl group, an optionally substituted alkyl group by 1 to 3 halogen atoms, a carboxyl group, a hydroxy group, a carboxyalkoxy group, a carboxyalkyl group, an alkoxycarbonylalkyl group, an oxo group, a cycloalkyl group, a hydroxyalkyl group, an alkoxyalkyl group, a carbamoyl group, a group mono- or dialkylcarbamoyl, an alkylcarbonylamino group, a morpholinyl group or a carboxyalkoxyalkyl group; qA is an integer from 0 to 3; or a pharmaceutically acceptable salt thereof.Un compuesto de fórmula (I-B) :**Fórmula** donde ZA es N o CH; A21A es un grupo alcoxi eventualmente substituido por 1 a 2 grupos seleccionados entr
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