Toray Industries, Inc.;Japan As Represented By Director-General Of National Institute Of Infectious Diseases;Tokyo Metropolitan Institute of Medical Science
发明人:
申请号：
EP10820650.9
公开号：
EP2484378A1
申请日:
2010.09.30
申请国别(地区):
EP
年份:
2012
代理人:
摘要：
A combination of an HCV antigen for inducing an antibody having the activity of inhibiting HCV infection and an optimum adjuvant is discovered, so as to provide an effective HCV vaccine composition. The hepatitis C virus vaccine composition comprises: inactivated viral particles obtained by inactivating infectious hepatitis C virus particles prepared from hepatitis C virus genome that contains sequences encoding NS3 protein, NS4A protein, NS4B protein, NS5A protein and NS5B protein derived from hepatitis C virus JFH1 strain；an oligonucleotide containing unmethylated CpG, according to SEQ ID NO: 5 in the sequence listing； andaluminium hydroxide.
