KUSHAKOVA, Anna Sergeevna,ALESHUNIN, Pavel Aleksandrovich,REKHARSKY, Mikhail Vladimirovich,MIKHAYLOV, Leonid Evgen,evich,GORBUNOVA, Svetlana Leonidovna,SMIRNOVA, Svetlana Sergeevna,KOZHEMYAKINA, Natal
申请号：
ECDI201943231
公开号：
ECSP19043231A
申请日:
2019.06.17
申请国别(地区):
EC
年份:
2019
代理人:
摘要：
One A compound of formula I: V2 V1 n R1 R6 r4r11 LR 3 N 1 or a stereoisomer, solution or pharmaceutically acceptable salt, wherein V1 is C or N, V2 is C (R2) or N, so if V1 is C, V2 is n, if V1 is C, V2 is C, if V1 is C, V2 is C, V2 is C, V2 is C, R2 is C, R2 is C, R2 is C, R2 is C, R2 is C, R2 is C, R2 is C, R2 is C, R2 is C, R2 is C, R2 is C, R2 is C, R2 is C, V2 is C, R2 is C, R2 is C, R2 is C,Or if V1 is n, V2 is C (R2)；Each n, K is an independent 0, 1； each R2, R 1 1 is an independent h, D, Hal, CN, nr'r '. "C（o）nr'r'，C1-C6； R3 is C1-C6 asphalt of H, D, hydroxy, C1-C6 of C1-C6, C1-C6 asphalt of alquinio (local authority) of c1-c, C1-C6 asphalt of C1-C6； R4 is h, Hal, CN, conr'r ',Hydrogen Xi, C1-C6 hydrocarbon, alcox C1-C6； Les CH2, NH, UF or chemical binding； R1 is selected from the following fragment groups: A1 A2 A4 A3 n or R5 R5 fragment 1, A1 A2 A4 A3 or A9 A8 A7 A6 A5 R5 fragment 2,1. Un compuesto de la Fórmula I: V2 V1 N N R1 R6 R4 R11 LR 3 n k Fórmula I o un estereoisómero, solvato o sal farmacéuticamente aceptable de este, en donde: V1 es C o N, V2 es C(R2) o N, de manera que si V1 es С entonces V2 es N, si V1 es С entonces V2 es С(R2), o si V1 es N entonces V2 es С(R2)； cada n, k es independientemente 0, 1； cada R2, R11 es independientemente H, D, Hal, CN, NR’R’’, C(O)NR’R’’, alcoxi C1-C6； R3 es H, D, hidroxi, alquilo С(O)C1-C6, alquenilo С(О)С2-С6, alquinilo С(О)С2-С6, alquilo C1-C6； R4 es H, Hal, CN, CONR’R’’, hidroxi, alquilo C1-C6, alcoxi C1-C6； L es CH2, NH, О o enlace químico； R1 se selecciona del grupo de fragmentos, que consiste en: A1 A2 A4 A3 N O R5 R5 Fragmento 1, A1 A2 A4 A3 O A9 A8 A7 A6 A5 R5 Fragmento 2,
