The present invention relates to hollow silica nanoparticles as a drug delivery system loading bioactive ingredients. Particularly, the present invention relates to silica nanoparticles comprising multi-layered silica shells with one or more bioactive ingredients encapsulated within and their applications in drug delivery； and processes of preparing the same.本發明涉及空心二氧化矽奈米粒子，其為裝載生物活性成分的藥物遞送系統。具體地說，本發明涉及包含多層二氧化矽殼體和一或多種囊封於該殼體內的生物活性成分的二氧化矽奈米粒子，以及其在藥物遞送中的應用；及涉及製備其之方法和應用。
