This disclosure provides protease-regulated antibodies which specifically bind to tissue factor pathway inhibitor (TFPI). The antibodies are useful for treating bleeding disorders such as hemophilia.本揭示內容提供特異結合至組織因子路徑抑制因子(TFPI)的經蛋白酶調控之抗體。該等抗體可用於治療出血性病症,諸如血友病。