UNIVERSITY OF MASSACHUSETTS;Eric M. Graban;Richard Vachet;RECLAIMRX, LLC
发明人:
Eric M. Graban,Richard Vachet,Yuping Zhou
申请号：
US15312434
公开号：
US10031143B2
申请日:
2015.05.21
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Some aspects of the disclosure include methods for comparing the higher order structures (HOS) of proteins using covalent labeling agents which allow for the direct comparison of changes in the HOS of protein therapeutics using mass spectrometry. The inventive methods can be used to access the effect of changing the process of producing and/or storing complex biologic compounds as well as determining if the HOS of a protein therapeutic has spontaneously changed during storage. Still other uses include comparing branded biologic therapeutic compounds to biosimilar compounds, and measuring changes in the aggregation states of proteins.
