YAN, WEI,PENTONY, MARTIN J.,BORGES, LUIS G.,MICHAELS, MARK L.
申请号:
CA2903258
公开号:
CA2903258C
申请日:
2014.03.13
申请国别(地区):
CA
年份:
2019
代理人:
摘要:
Provided herein are heterodimeric bispecific antibodies that can mediate cytolysis of a target cell by an immune effector cell, nucleic acids encoding such antibodies, methods of making such antibodies, and methods of using such antibodies. These antibodies comprise two different polypeptide chains, each comprising two immunoglobulin variable regions and, optionally, a half life-extending moiety.