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COMPOSITIONS AND METHODS FOR Oral Administration of Exenatide
专利权人:
ОРАМЕД ЛТД. (IL)
发明人:
КИДРОН Мириам (IL)
申请号:
RU2010146372/15
公开号:
RU2010146372A
申请日:
2009.05.03
申请国别(地区):
RU
年份:
2012
代理人:
摘要:
1. A composition comprising exenatide, a protease inhibitor, and omega-3 fatty acid, said composition being a pharmaceutical composition for oral administration. ! 2. The composition according to claim 1, characterized in that said omega-3 fatty acid is obtained from fish oil. ! 3. The composition according to claim 1, characterized in that said inhibitor is a soybean trypsin inhibitor. ! 4. The composition according to claim 1, characterized in that said protease is a serine protease. ! 5. The composition according to claim 1, characterized in that said protease is trypsin. ! 6. The composition according to claim 1, additionally containing a substance that enhances the absorption of exenatide through the barrier of the intestinal mucosa. ! 7. The composition according to claim 6, characterized in that the substance is EDTA or its salt. ! 8. The composition according to claim 6, characterized in that said substance is bile acid or a salt of said acid and alkali metal. ! 9. The composition of claim 1, further comprising a coating that inhibits exenatide cleavage in the stomach of the subject. ! 10. The composition according to claim 9, characterized in that said coating is an enteric coating or gelatin coating. ! 11. The composition according to claim 1 for the treatment of diabetes. ! 12. The composition according to claim 1 for reducing food intake by the subject. ! 13. A composition according to any one of claims 11 and 12, wherein said omega-3 fatty acid is derived from fish oil. ! 14. The composition according to any one of paragraphs.11 and 12, characterized in that said inhibitor is a soybean trypsin inhibitor. ! 15. The composition according to any one of cl1. Композиция, содержащая эксенатид, ингибитор протеазы и омега-3 жирную кислоту, причем указанная композиция представляет собой фармацевтическую композицию для перорального применения. ! 2. Композиция по п.1, отличающаяся тем, что указанная омега-3 жирная кислота получена из рыбьего жира. ! 3. Композици
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