DIRK LEYSEN,OLIVIER DEFERT,SANDRO BOLAND,JO ALEN,ARNAUD, PIERRE, JEAN BOURIN
申请号：
MX2013012555
公开号：
MX2013012555A
申请日:
2012.04.27
申请国别(地区):
MX
年份:
2014
代理人:
摘要：
The present invention relates to new kinase inhibitors of Formula (I), wherein X is oxygen, -NH-, or a direct bond Y is -NH- or a direct bond n is an integer from 0 to 4 m is an integer from 0 to 4 Cy represents a bivalent radical consisting of a satured (poly)cycle, including fused, bi-, spiro or bridged carbocycles and heterocycles in particular selected from the group consisting of:Formula (II), Ar is selected from the group comprising: Formula (III), R2 is hydrogen or methyl R8 is hydrogen, methyl, halogen, or alkynyl R1 is an aryl or heteroaryl more specifically ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In particular, the present invention relates to new ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In addition, the invention relates to methods of treatment and use of said compounds in the manufacture of a medicament for the application to a number of therapeutic indications including sexual dysfunction, inflammatory diseases, ophthalmic diseases and Respiratory diseases.La presente invención se refiere a nuevos inhibidores de quinasa más específicamente, inhibidores de ROCK, a composiciones, en particular composiciones farmacéuticas que comprenden tales inhibidores, y a los usos de esos inhibidores en el tratamiento y la profilaxis de enfermedades. En particular, la presente invención se refiere a nuevos inhibidores de ROCK, a composiciones, en particular composiciones farmacéutica, que comprenden tales inhibidores y a los usos de esos inhibidores en el tratamiento y la profilaxis de enfermedades. Además, la invención se refiere a métodos de tratamiento y uso de dichos compuestos en la fabricación de un medicamento para la aplicación de muchas indicciones terapéuticas, incluyendo la disfunción sexual, las enfermedades in
