As for this invention, mixing with the suitable carrier, as a active ingredient professional anthocyanidin independence or gurichirurechin acid and Telecom female theine, with the medicine composition for local dosage which includes the fact that it combines with - bisabororu or the other component which possesses complimentary activity, for example, it remedies the various conditions the atopic characteristic dermatitis, the allergy characteristic contact dermatitis, the fat characteristic dermatitis, the radioactive dermatitis, the dry , xerosis and the atopic way, and it is useful in remedy of condition of the catarrh.本発明は、適当な担体と混合して、活性成分としてプロアントシアニジン単独、またはグリチルレチン酸、テルメステイン、α-ビサボロールもしくは相補的な活性を有する他の成分と組み合わせることを含む局所投与用医薬組成物で、例えば、アトピー性皮膚炎、アレルギー性接触皮膚炎、脂漏性皮膚炎、放射性皮膚炎、乾癬、乾燥症およびアトピーような様々な症状を治療、並びに粘膜炎症の症状の治療に有用である。