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PREPARATION PHARMACEUTIQUE SOLIDE, ET PROCEDE DE STABILISATION DE CELLE-CI
专利权人:
LTD.;EA PHARMA CO.
发明人:
ANDO, TAKAHIKO,HAGIO, HIROKAZU,MATSUSHITA, TAKASHI,ITO, YUSUKE,SUGIURA, MAKOTO
申请号:
CA2952405
公开号:
CA2952405A1
申请日:
2015.06.24
申请国别(地区):
CA
年份:
2015
代理人:
摘要:
The present invention pertains to stabilization of a certain class of benzothia(dia)zepine derivative in a solid preparation containing the derivative. The present invention provides a solid preparation containing (A) the benzothia(dia)zepine derivative, and (B) a specific plasticizer, wherein either the component (A) and the component (B) are isolated, or, when the component (A) and the component (B) are not isolated, the component (B) content is no more than 0.9 wt.% based on the total weight of the solid preparation. The solid preparation is formed so as to be provided with at least one core, and at least one sheath layer or capsule layer enveloping at least a portion of the core, the component (A) being blended into the core, and the component (B) being blended into the sheath layer or capsule layer. The component (B) content of the sheath layer or capsule layer is no more than 45 wt.% based on the total weight of the sheath layer or capsule layer.
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中国工程科技知识中心
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http://www.ckcest.cn/home/

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