The invention provides methods for preparing pharmaceutical formulations for injection such that upon injection the formulation does not cause erythrocyte agglutination, hemolysis, and/or cell shrinkage. To prevent agglutination, a pharmaceutical formulation ready for injection needs to have a sufficient ionic strength. To prevent hemolysis or cell shrinkage, a pharmaceutical formulation ready for injection needs to be about isotonic with respect to plasma. The invention provides methods that prepare pharmaceutical formulations for injection that have both the sufficient ionic strength to prevent agglutination and the requisite tonicity to prevent significant hemolysis or cell dehydration or shrinkage. The present methods involve the use of sodium chloride solutions that are about 25 mM to about 150 mM for reconstituting lyophilized cakes (or other non-liquid pharmaceutical formulations) into solution or for diluting pharmaceutical formulation solutions.本發明提供用於配製一藥學配方以供注射的方法，而使得當注射之時，該配方不會造成紅血球凝集、溶血和/或細胞萎縮。為防止凝集，一能立即供注射用的藥學配方需要具有一足夠的離子強度。為防止溶血或細胞萎縮，一能立即供注射用的藥學配方對於血漿而言需要是大約等滲壓的。本發明提供配製藥學配方以供注射的方法，該等藥學配方具有足夠的離子強度以防止凝集以及必要的滲壓性以防止明顯的溶血或細胞脫水或萎縮。本案方法涉及使用大約25 mM至大約150 mM的氯化鈉溶液以將經冷凍乾燥的餅塊(或其他非液態的藥學配方)復原成為溶液或用以稀釋藥學配方溶液。
