THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人:
LYNN, RACHEL,MACKALL, CRYSTAL,WANDLESS, TOM J.,WEBER, EVAN
申请号：
CA3057372
公开号：
CA3057372A1
申请日:
2018.03.30
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The present invention relates to T cell compositions and methods of using the same in the context of therapy and treatment. In particular, the invention provides chimeric antigen receptor (CAR) T cells that are modified to maintain functionality under conditions in which unmodified CAR T cells display exhaustion. Compositions and methods disclosed herein find use in inhibiting or reversing CAR T cell exhaustion (e.g., by modulating CAR surface expression) thereby enhancing CAR T cell function. Compositions and methods of the invention find use in both clinical and research settings, for example, within the fields of biology, immunology, medicine, and oncology.
