This invention relates to combinations of vasoactive substances which areuseful in the treatment of sexual dysfunctions associated with poor localblood supply and/or insufficient lubrication. The active compounds areselected from a: - esculoside or visnadine； - forskolin or extracts containingit, or alternatively, purified lipophilic extracts of plants of the genusIpomea； - esters of ximenynic acid； - optionally, at least one compoundselected from a icarin or derivatives or extracts thereof which contain it,amentoflavone, and Gingko biloba dimeric flavones. The combination of thesevasoactive substances is incorporated in gels and lotions designed to beapplied to the genital organs. These formulations are useful in inducingerection of the male and female sex organs and enhancing orgasm and sexualperformance. The formulations are particularly useful in the treatment offemale sexual dysfunctions.
