Chao Zhang,James Tsai,Jiazhong Zhang,Prabha N. Ibrahim,Todd Ewing,Wayne Spevak,Ying Zhang
申请号：
BR112012026927
公开号：
BR112012026927A2
申请日:
2011.04.20
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
compound and methods for kinase modulation, and indications therefor. The present invention relates to the compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. in certain aspects and embodiments, the disclosed compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof, are active in one or more of the fms, kit, flt3, trkb and trkc protein kinase. Also described are methods of using them to treat diseases and conditions, including diseases and conditions associated with the activity of one or more of fms, kit, flt3, trka, trkb and trkc, including rheumatoid arthritis, osteoarthritis, osteoporosis, periprosthetic osteolysis, systemic sclerosis, demyelinating disorders, multiple sclerosis, charcot marie tooth syndrome, amyotrophic lateral sclerosis, alzheimer's disease, parkison's disease, global ischemia, ulcerative colitis, crohn's disease, thrombocytopenic purpura, atherosclerosis, systemic lupus erythematosus, transplantation autologous, transplant rejection, glomerulonephritis, lupus nephritis, tubular necrosis, diabetic nephropathy, renal hypertrophy, type i diabetes, acute pain, inflammatory pain, neropathic pain, acute myeloid leukemia, melanoma, multiple myeloma, breast cancer, prostate cancer , pancreatic cancer, lung cancer, ovarian cancer, gliomas, gli blastoma, neurofibromatosis, osteolytic bone metastasis, brain metastasis, gastrointestinal stromal tumors, and giant cell tumors.composto e métodos para modulação de cinase, e indicações para os mesmos. a presente invenção refere-se aos compostos e sais dos mesmos, formulações dos mesmos, conjugados dos mesmos, derivados dos mesmos, formas dos mesmos e usos dos mesmos são descritos. em certos aspectos e modalidades, os compostos descritos ou sais dos mesmos, formulações dos mesmos, conjugados dos mesmos, derivados dos mesmos, formas dos mesmos, são ativos em uma ou mais das prote
