The invention provides a polypeptide for use in suppressing or treating itch wherein the polypeptide comprises: a non cytotoxic protease which protease is capable of cleaving a SNARE protein in an itch specific DRG neuron or a pruriceptor a Targeting Moiety (TM) that is capable of binding to a Binding Site on the itch specific DRG neuron or a pruriceptor which Binding Site is capable of undergoing endocytosis to be incorporated into an endosome within the itch specific DRG neuron or a pruriceptor and wherein said itch specific DRG neuron or a pruriceptor expresses said SNARE protein and a translocation domain that is capable of translocating the protease from within an endosome across the endosomal membrane and into the cytosol of the itch specific DRG neuron or a pruriceptor with the proviso that the polypeptide is not a clostridial neurotoxin (holotoxin) molecule.
