THE UNIVERSITY OF QUEENSLAND;THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, AND THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
发明人:
O'NEILL, Luke,COLL, Rebecca,COOPER, Matt,ROBERTSON, Avril,SCHRODER, Kate
申请号：
PE2017001395
公开号：
PE20180160A1
申请日:
2016.02.16
申请国别(地区):
PE
年份:
2018
代理人:
摘要：
It refers to the compounds produced in the preparation of (I), where W is O, s or s； J is s and S； R1 is cyclopropene, arilo, isopropene, etc.； R2 is arilo, isopropene, isopropene, etc. The most popular compounds are n - ((2,5-methoxyphenyl) amino-1) - 4 - (2-hydroxypropane-2-il) furan-2-sulfur amide, N - (4-chloro-2,6-dimethylphenyl) amino-4 - (2-hydroxypropane-2-il) furan-2-sulfur amide, etc. He also mentioned a pharmaceutical composer These compounds inhibit the ignition of protein 3, which contains the pyridine domain (nrp3), and are useful in the treatment of inflammatory disorders.SE REFIERE A COMPUESTOS DERIVADOS DE SULFONILUREAS DE FORMULA (I) DONDE W ES O, S O Se； J ES S Y Se； R1 ES CICLOALQUILO, ARILO, HETEROARILO, ENTRE OTROS； R2 ES ARILO, HETEROARILO, HETEROCICLILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N-((2,5-DIMETOXIFENIL)CARBAMOIL)-4-(2-HIDROXIPROPAN-2-IL)FURAN-2-SULFONAMIDA； N-((4-CLORO-2,6-DIMETILFENIL)CARBAMOIL)-4-(2-HIDROXIPROPAN-2-IL)FURAN-2-SULFONAMIDA； ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA ACTIVACION DEL INFLAMASOMA DE LA PROTEINA 3 QUE CONTIENE DOMINIO DE PIRINA (NLRP3) SIENDO UTILES EN EL TRATAMIENTO DE TRASTORNOS QUE IMPLICAN INFLAMACION
