ДЗЕ РЕГЕНТС ОФ ДЗЕ ЮНИВЕРСИТИ ОФ КАЛИФОРНИЯ (US); ИНК. (US);ОТОНОМИ;ОТОНОМИ, ИНК. (US)
发明人:
ЛИХТЕР Джей (US),ФОЛЛЬРАТ Бенедикт (US),ТРЭММЕЛ Эндрю М. (US),ДЮРОН Сергио Г. (US),ПЬЮ Фабрис (US),ДЕЛЛАМЭРИ Луис А. (US),Е Цян (US),ЛЕБЕЛ Карл (US),СКАЙФ Майкл Кристофер (US),ХАРРИС Джеффри П. (US)
申请号：
RU2011105257/15
公开号：
RU2011105257A
申请日:
2009.07.09
申请国别(地区):
RU
年份:
2012
代理人:
摘要：
1. A sterile pharmaceutical composition for use in the treatment of diseases of the ear by intra-drum injection into the membrane of the cochlear window or near the membrane of the cochlear window, containing a thermally reversible, water-soluble gel suitable for treating the ear, containing a polymer of polyoxypropylene and polyoxyethylene and an anti-apoptotic agent, with a delayed release of the anti-apoptotic agent into the cochlea for at least 4 days. ! 2. The composition of claim 1, wherein the anti-apoptotic agent inhibits the MAPK / JNK signaling cascade. ! 3. The composition according to claim 1, in which the auris-acceptable thermally reversible water-soluble gel containing a polymer of polyoxypropylene and polyoxyethylene is Poloxamer 407.! 4. The composition according to claim 1 for the treatment of acoustic trauma. ! 5. The composition according to claim 1, in which the anti-apoptotic agent is selected from the group: minocycline； SB-203580 (4- (4-fluorofinyl) -2- (4-methylsulfinyl phenyl) -5- (4-pyridyl) 1H-imidazole)； PD 169316 (4- (4-fluorophenyl) -2- (4-nitrophenyl) -5- (4-pyridyl) -1H-imidazole)； SB 202190 (4- (4-fluorophenyl) -2- (4-hydroxyphenyl) -5- (4-pyridyl) 1H-imidazole)； RWJ-67657 (4- [4- (4-fluorophenyl) -1- (3-phenylpropyl) -5- (4-pyridinyl) -1H-imidazol-2-yl] -3-butyn-1-ol)； SB 220025 (5- (2-amino-4-pyrimidinyl) -4- (4-fluorofinyl) -1- (4-piperidinyl) imidazole)； SP 600125 (anthra [1.9-cd] pyrazol-6 (2H) -one), AS601245 (1,3-benzothiazol-2-yl (2 - [[2- (3-pyridinyl) ethyl] amino] -4pyrimidinyl ) acetonitrile), JNK modulator VI (H2N-RPKRPTTLNLF-NH2), JNK modulator VIII (N- (4-amino-5-cyano-6-ethoxypyridin-2-yl) -2- (2,5-dimethoxyphenyl) acetamide) , JNK modulator IX (N- (3-cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl) -1-naphthamide), dicumarol (3,3'-methylenebis (4-hydroxycoumarin)) , SC-236 (4- [5- (4-chlorophenyl) -3- (trifluoromethyl) -1H-pyrazol-1-yl] benzenesulfamide), SER-1347 (Cephalon) and SER-11004 (Cephalon), il1. Стерильная фарм
