An automated blood sampler integratable with a glucose monitor comprises a catheter connected to a tube-set forming a single blood passageway a clamp-on air-bubble sensor and a occlusion sensor externally attached to the tube set a single peristaltic pump and two 3-way pinch valves attached to the tube set and control fluid flow. The sampler draws blood from a stationary patient, samples the blood for analytical measurement of blood parameters after which the passageway is rinsed, the blood re-infused, and slow saline infusion prevents vein collapse. The cycle repeats at user or predefined intervals. In another preferred embodiment, blood is not re-infused, and only one 3-way pinch valve is used.
