An intraluminal sensing system is provided. The intraluminal sensing system includes a patient interface module (PIM) in communication with an intraluminal device comprising a physiologic sensor and positioned within a body lumen of a patient, a wireless router via a signal link, and a computing device in wireless communication with the wireless router, wherein the PIM comprises a processing component configured to receive a sensor signal from the physiologic sensor; and determine physiologic data based on at least the sensor signal; and a power and communication component configured to receive power from the signal link; and transmit, to the computing device via the signal link and the wireless router, the physiologic data.