Rhode Island Council on Postsecondary Education;Yale University
发明人:
Yana K. Reshetnyak,Oleg A. Andreev,Anna Moshnikova,Donald M. Engelman
申请号：
US16774966
公开号：
US20200237926A1
申请日:
2020.01.28
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The invention features a composition comprising a potent cytotoxic compound and a pHLIP® peptide, where, e.g., the cytotoxic compound cannot be used alone due to a lack of targeting. pHLIP® peptide targets cytotoxic compounds to acidic diseased tissue, translocates cytotoxic compounds across plasma membranes into the cytosols of cells in acidic diseased tissues and induces cell death predominantly in the targeted acidic diseased tissue.
