Wisconsin Alumni Research Foundation;The Regents of the University of California
发明人:
Ronald T. Raines,Julie C. Mitchell,Thomas J. Rutkoski
申请号：
US14335386
公开号：
US09255260B2
申请日:
2014.07.18
申请国别(地区):
US
年份:
2016
代理人:
摘要：
This invention relates to altered forms of members of the RNase A superfamily. An RNase A can be modified to be cytotoxic by altering its amino acid sequence so that it is not bound easily by the ribonuclease inhibitor while still retaining catalytic properties. While earlier work had identified some modifications to RNase A that would result in cytotoxicity, the use of the FADE algorithm for molecular interaction analysis has led to several other locations that were candidates for modification. Some of those modifications did result in RNase A variants with increase cytotoxicity.
