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Carbohydrate ligands that bind to antibodies against glycoepitopes of glycosphingolipids
专利权人:
Universität Basel
发明人:
Herrendorff, Ruben,Ernst, Beat,Steck, Andreas,Pfister, Héléne,Navarra, Giulio
申请号:
AU2016323377
公开号:
AU2016323377A1
申请日:
2016.09.14
申请国别(地区):
AU
年份:
2018
代理人:
摘要:
The invention relates to carbohydrate ligands and moieties, respectively, mimicking glycoepitopes comprised by glycosphingolipids of the nervous system, particularly glycoepitopes comprised by glycosphingolipids of the cerebroside, the globoside-, the ganglioside- and the sulfoglucuronyl paragloboside type, which are bound by anti-glycan antibodies associated with neurological diseases. The invention further relates to the use of these carbohydrate ligands/moieties, in diagnosis as well as for the treatment of neurological diseases associated with anti-glycan antibodies. In particular, the invention relates to compounds of formula (I) and (II) and to therapeutically acceptable polymers comprising a multitude of these compounds, including polymers with loading of one compound of formula (I) or (II) or combinations of several compounds of formula (I), and/or (II). The compounds of formula (I) are defined as: formula (I), wherein R
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