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ANTICORPS CHIMÈRES ET HUMANISÉS ANTI-CD44 INFLUENÇANT LA CYTOTOXICITÉ DES CELLULES CANCÉREUSES
专利权人:
F.HOFFMANN-LA ROCHE AG
发明人:
YOUNG, DAVID, S. F.,FINDLAY, HELEN, P.,HAHN, SUSAN, E.,CECHETTO, LISA, M.,MC-CONKEY, FORTUNATA
申请号:
EP08757120
公开号:
EP2164874A4
申请日:
2008.05.23
申请国别(地区):
EP
年份:
2013
代理人:
摘要:
This invention relates to the staging, diagnosis and treatment of cancerous diseases (both primary tumors and tumor metastases), particularly to the mediation of cytotoxicity of tumor cells; and most particularly to the use of cancerous disease modifying antibodies (CDMAB), optionally in combination with one or more CDMAB/chemotherapeutic agents, as a means for initiating the cytotoxic response. The invention further relates to binding assays, which utilize the CDMAB of the instant invention. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, cytokines, interferons, target or reporter moieties and hematogenous cells.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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