Tjoelker Larry W.,Cummings W. Jason,Gray Patrick,Yabuki Munehisa
申请号：
NZ62968214
公开号：
NZ629682A
申请日:
2014.03.14
申请国别(地区):
NZ
年份:
2017
代理人:
摘要：
Disclosed is an isolated antibody, or antigen-binding fragment thereof, comprising a MASP1 or MASP2 inhibiting bioactive peptide amino acid sequence, wherein the bioactive peptide amino acid sequence comprises an SGMI core amino acid sequence and is fused to at least one of: (i) the amino terminal region of at least one of: a light chain variable region and/or a heavy chain variable region or (ii) the carboxy terminal region of at least one of: a light chain constant region and/or a heavy chain constant region, wherein the antibody inhibits complement activation.
