It refers to a method for purifying one or more cannabis phenols from plant materials, including: (a) cultivating plant materials with the first non-polar solvent to form the first solvent mixture from which one or more cannabis phenols are extracted； and (b) reducing the volume of the first solvent mixture to about 50%. (c) incubate the first reduced mixture between - 70 ℃ and 40 ℃ to crystallize one or more cannabinoids； (d) cultivate one or more crystallized cannabinoids, supplemented by the second non-polar solvent, to form a second solvent mixture to dissolve at least 50% of the crystallized cannabinoids；(E) incubate a second solvent mixture between - 70 ° C and 40 ° C to crystallize one or more pure cannabinoides. In addition, the method also includes purifying the crystallized cannabinoids through filtration, so as to collect the mother liquor, and cultivating the liquor by crystallizing one or more cannabinoids under the condition of 70 ° C to 40 ° C. He also mentioned a pharmaceutical composer This method can get pure cannabinoides in the treatment of schizophrenia, inflammation, spasms and so on.Se refiere a un metodo de purificacion de uno o mas cannabinoides a partir de material vegetal que comprende: a) incubar el material vegetal con un primer disolvente no polar para formar una primera mezcla de disolventes en el cual se extrae uno o mas cannabinoides； b) reducir el volumen de la primera mezcla de disolvente a aproximadamente 50% del volumen original； c) incubar la primera mezcla reducida entre -70°C a 40°C de manera que cristalice uno o mas cannabinoides； d) incubar uno o mas cannabinoides cristalizados con un segundo disolvente no polar para formar una segunda mezcla de disolvente en el que se disuelve al menos el 50% de los cannabinoides cristalizados； e) incubar la segunda mezcla de disolventes entre entre -70°C a 40°C de manera que cristalice uno o mas cannabinoides purificados. Adicionalmente, el metodo comprende purificar los cannabinoides cris
