Provided are methods for the modulation of chronic visceral inflammation in a cell, tissue, organ and/or subject using miRNA agents. Also provided are miRNA agents (e.g., miRNA, agomirs, and antagomirs) that can modulate the level of chronic inflammation and methods of screening for such agents. Also provided are compositions (e.g., aptamirs or exomirs) that facilitate cell/tissue-specific delivery of the miRNA agents.
