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STABILIZED FORMULATIONS OF LIPID NANOPARTICLES
专利权人:
ModernaTX; Inc.
发明人:
Mark BRADER
申请号:
US16348335
公开号:
US20190336452A1
申请日:
2017.11.08
申请国别(地区):
US
年份:
2019
代理人:
摘要:
The disclosure features a lipid nanoparticle (LNP) formulation comprising a plurality of LNPs and a stabilizing agent that mitigates the degradation of the LNPs or a subpopulation thereof. Lipid nanoparticles further including therapeutics and/or prophylactics such as RNA are useful in the delivery of therapeutics and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression. Methods of manufacturing LNP formulations and screening for a stabilizing agent are also disclosed.
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中国工程科技知识中心
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http://www.ckcest.cn/home/

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