Ogari de Castro Pacheco;Roberto Carlos Debom Moreira;Krishnamurti De Morais Carvalho;Maria Denise Fernandes Carvalho;Dòris Maria Fernandes Carvalho
发明人:
Krishnamurti De Morais Carvalho,Dòris Maria Fernandes Carvalho,Maria Denise Fernandes Carvalho,Ogari de Castro Pacheco,Roberto Carlos Debom Moreira
申请号：
US13322917
公开号：
US08541395B2
申请日:
2010.05.26
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention is directed to the use of telocinobufagin, or its pharmaceutically acceptable derivatives, in the manufacture of a medicament for the treatment or prevention of acute and chronic pains. The present invention also refers to a pharmaceutical composition comprising an effective amount of telocinobufagin； also provides a method to induce analgesia in response to acute and chronic pains that comprehends administering an effective amount of telocinobufagin to human beings or animals. According to the outcomes of in vivo assays, telocinobufagin is more potent than morphine, though without presenting the known side effects of opioids. In addition, in vivo and in vitro essays showed that TBC does not present cardiotoxicity.
