SENTER PETER,TIBERGHIEN ARNAUD,MASTERSON LUKE,BURKE PATRICK,JEFFREY SCOTT,HOWARD PHILIP WILSON
申请号：
NZ60293311
公开号：
NZ602933A
申请日:
2011.04.15
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
Disclosed herein is a compound of the formula I, wherein the variables are defined herein a conjugate of the formula III, L &ndash (LU-D)p, wherein L is a Ligand unit, LU is a Linker unit, p is 1 to 20, and D is a Drug unit of formula I and the use of said conjugate for treating a proliferative disease or an autoimmune disease. Specific embodiments of the compound include (S)-2-(4-aminopheny/)-7-methoxy-8-(3-((S)-7-methoxy-2-(trifluoromethylsulfonyl)-5,11-dioxo-10-((2-(trimethylsilyl)ethoxy)methyl)-5,10,11,11a-tetrahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepin-8-yloxy)propoxy)-10-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11(10H, 11aH)-dione.
