Univ;The Provost, Fellows, Foundation Scholars, and the other Members of Board, of the College of the Holy and Undivided Trinity of Queen Elizabeth, near Dublin;Royal Melbourne Institute of Technology
发明人:
Selemidis, Stavros,Brooks, Doug A.,O'Leary, John
申请号：
AU2018293925
公开号：
AU2018293925A1
申请日:
2018.06.29
申请国别(地区):
AU
年份:
2020
代理人:
摘要：
The present invention relates generally to the field of immunomodulation. Taught herein is an agent for inhibiting immunostimulation mediated by a Toll-like receptor useful in the treatment of viral and microbial pathogenesis, diseases involving elements of autoimmunity and inflammation as well as cancer. The agent antagonizes disulfide bond formation between C98 and C475 of Toll-like receptor 7 (TLR7) thereby preventing TLR7 activation.Pharmaceutical compositions are also enabled herein.
