Compound having an excellent inhibitory Action Against Blood coagulation factor VIIa and anticoagulant Action, reaches a level sufficient to express its pharmacological actions. Accordingly, the application of this Compound is useful as a preventive and / or therapeutic agent for Diseases caused by thrombus formation.Claim 1: a compound represented by the formula (1) or a pharmaceutically acceptable salts thereof wherein R1 represents phenyl optionally substituted with one to Three 6 - alkoxy alkyl groups C1, C1 or C2 alquenil - 6 - 6 - Oxy； R2 represents a hydrogen Atom, alkyl C1 6 - carbonyl or piridilcarbonilo； R3 and R4 represent each, independently,A Hydrogen Atom, alkyl or C1 - 6； a represents a Single Bond, an oxygen Atom, a group represented by the formula (2) with ra and RB are each independently a hydrogen Atom or alkyl and C1 - 6 * 1 and 2 * involve ligation with carbonyl and R5, respectiv Time, in the formula (1), or a group represented by the formula (3) where RC, RD,Re and RF are each independently a hydrogen Atom or alkyl C1 - 6 and * * 1 and 2 have the same meaning as those described previously； and R5 C1 represents alkyl or cycloalkyl - 6 - 8 C3 and C1 - C3 alkyl or cycloalkyl - 6 8In R5 is optionally substituted with one to three equal or different substituents selected from the group consisting of substituents in a Halogen Atom, alkyl and alkoxy C1 C1 - 6 - 6.Compuesto que tiene una excelente acción inhibidora contra el factor de coagulación sanguínea VIIa y la acción anticoagulante, alcanza un nivel suficiente para expresar sus acciones farmacológicas. En consecuencia, el compuesto de la presente solicitud es de utilidad como un agente terapéutico y/o preventivo para enfermedades causadas por formación de trombos.Reivindicación 1: Un compuesto representado por la fórmula (1) o una de sus sales farmacéuticamente aceptables caracterizado porque R1 representa fenilo opcionalmente sustituido con uno a tres grupos alquilo C1-6, alcoxi C1-6 o alquenil
