Dual inhibitors of TIM-3 and PD-1 pathways

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专利权人:

Aurigene Discovery Technologies Limited

发明人:

SASIKUMAR, Pottayil Govindan Nair,RAMACHANDRA, Muralidhara,NAREMADDEPALLI, Seetharamaiah Setty Sudarshan,GOWDA, Nagaraj

申请号：

AU2018360386

公开号：

AU2018360386A1

申请日:

2018.10.31

申请国别(地区):

AU

年份:

2020

代理人:

摘要：

The present disclosure relates to 3-substituted 1,2,4-oxadiazole compounds and their derivatives, which are useful as T-cell immunoglobulin and mucin-domain containing-3 (TIM-3) inhibitors or as dual inhibitors of TIM-3 and the programmed cell death 1 (PD-1) signaling pathway. The disclosure also relates to treatment of disorders by inhibiting an immunosuppressive signal induced by TIM-3, PD-1, PD-Ll, and/or PD- L2.

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