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Dual inhibitors of TIM-3 and PD-1 pathways
专利权人:
Aurigene Discovery Technologies Limited
发明人:
SASIKUMAR, Pottayil Govindan Nair,RAMACHANDRA, Muralidhara,NAREMADDEPALLI, Seetharamaiah Setty Sudarshan,GOWDA, Nagaraj
申请号:
AU2018360386
公开号:
AU2018360386A1
申请日:
2018.10.31
申请国别(地区):
AU
年份:
2020
代理人:
摘要:
The present disclosure relates to 3-substituted 1,2,4-oxadiazole compounds and their derivatives, which are useful as T-cell immunoglobulin and mucin-domain containing-3 (TIM-3) inhibitors or as dual inhibitors of TIM-3 and the programmed cell death 1 (PD-1) signaling pathway. The disclosure also relates to treatment of disorders by inhibiting an immunosuppressive signal induced by TIM-3, PD-1, PD-Ll, and/or PD- L2.
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