Smith, Graeme Caameron Murray,Hummersone, Marc Geoffrey,Gomez, Sylvie,Menear, Keith Allan,Malagu, Karine,Duggan, Heather Mary Ellen,Cockcroft, Xiao-ling Fan,Hermann, Gesine Johanna
申请号:
NO20082101
公开号:
NO341055B1
申请日:
2008.05.06
申请国别(地区):
NO
年份:
2017
代理人:
摘要:
There is provided a compound of formula I: wherein: one or two of X<;SUP>;5<;/SUP>;, X<;SUP>;6 <;/SUP>;and X<;SUP>;8 <;/SUP>;is N, and the others are CH; R<;SUP>;7 <;/SUP>;is selected from halo, OR<;SUP>;O1<;/SUP>;, SR<;SUP>;S1<;/SUP>;, NR<;SUP>;N1<;/SUP>;R<;SUP>;N2<;/SUP>;, NR<;SUP>;N7a<;/SUP>;C(-O)R<;SUP>;C1<;/SUP>;, NR<;SUP>;N7b<;/SUP>;SO<;SUB>;2<;/SUB>;R<;SUP>;S2a<;/SUP>;, an optionally substituted C<;SUB>;5-20 <;/SUB>;heteroaryl group, or an optionally substituted C<;SUB>;5-20 <;/SUB>;aryl group, where R<;SUP>;O1 <;/SUP>;and R<;SUP>;S1 <;/SUP>;are selected from H, an optionally substituted C<;SUB>;5-20 <;/SUB>;aryl group, an optionally substituted C<;SUB>;5-20 <;/SUB>;heteroaryl group, or an optionally substituted C<;SUB>;1-7 <;/SUB>;alkyl group; R<;SUP>;N1 <;/SUP>;and R<;SUP>;N2 <;/SUP>;are independently selected from H, an optionally substituted C<;SUB>;1-7 <;/SUB>;alkyl group, an optionally substituted C<;SUB>;5-20 <;/SUB>;heteroaryl group, an optionally substituted C<;SUB>;5-20 <;/SUB>;aryl group or R<;SUP>;N1 <;/SUP>;and R<;SUP>;N2 <;/SUP>;together with the nitrogen to which they are bound form a heterocyclic ring containing between 3 and 8 ring atoms; R<;SUP>;C1 <;/SUP>;is selected from H, an optionally substituted C<;SUB>;5-20 <;/SUB>;aryl group, an optionally substituted C<;SUB>;5-20 <;/SUB>;heteroaryl group, an optionally substituted C<;SUB>;1-7 <;/SUB>;alkyl group or NR<;SUP>;N8<;/SUP>;R<;SUP>;N9<;/SUP>;, where R<;SUP>;N8 <;/SUP>;and R<;SUP>;N9 <;/SUP>;are independently selected from H, an optionally substituted C<;SUB>;1-7 <;/SUB>;alkyl group, an optionally substituted C<;SUB>;5-20 <;/SUB>;heteroaryl group, an optionally substituted C<;SUB>;5-20 <;/SUB&g