The present invention relates to a cosmetic or pharmaceutical composition for topical application comprising, in a cosmetically or pharmaceutically acceptable medium, a combination of pectin (e440) and of an extract of centella asiatica, to the use of such a composition in order to prevent or reduce the adhesion of the microorganism to the surface of the skin and / or mucous membranes, to a cosmetic process nontherapeutic care of the skin using such a cosmetic composition, and the use of such a pharmaceutical composition in the prevention and / or the treatment of cutaneous lesions, and in particular in the prevention and / or the treatment of bedsores and ischaemic.