YAN, XIAOQIANG,HUANG, ZHIHUA,YANG, HONGZHOU,SUN, BILL N.C.,HUANG, YULIANG
申请号：
EP11786091
公开号：
EP2576624A4
申请日:
2011.05.25
申请国别(地区):
EP
年份:
2013
代理人:
摘要：
Provided is a recombinant human G-CSF (rhG-CSF) dimer having prolonged serum half-life and increased biological activity of G-CSF, wherein the dimer is produced by two G-CSF-Fc complexes through the pairing of two Fc fragments via disulfide bonds, and the G-CSF-Fc complex comprises a G-CSF monomer, an Fc fragment of human IgG2, and a peptide connecting the G-CSF monomer and the Fc fragment. The rhG-CSF can be used for the treatment of neurological diseases.
