OFNER, CLYDE M., III.,CAMMARATA, CHRIS,RHODES, BRIAN,WU, DARREN
申请号：
CA2966598
公开号：
CA2966598A1
申请日:
2015.10.30
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
Disclosed herein are high molecular weight compounds comprising gelatin and doxorubicin, where the gelatin is covalently linked to doxorubicin through a cleavable linker. The cleavable linker can be cleaved under appropriate physiological conditions, and thus lead to the freeing of doxorubicin. The free doxorubicin can then exert its cytotoxic effects on cancer cells. Disclosed herein are methods of making the high molecular weight gelatin-doxorubicin conjugates and methods of use of the same.
