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Weakly acidic pH-responsive peptide and liposome containing same
专利权人:
发明人:
Kentaro Kogure,Susumu Hama
申请号:
US14430723
公开号:
US09526791B2
申请日:
2013.10.21
申请国别(地区):
US
年份:
2016
代理人:
摘要:
A problem to be solved by the present invention is to provide a peptide compound for producing a drug delivery carrier capable of releasing a target substance in a weakly acidic pH environment. The present invention provides a peptide compound comprising a hydrophilic amino acid block and a hydrophobic amino acid block [1] the peptide compound containing 24 to 36 amino acids in total [2] the hydrophilic amino acid block containing 4 to 10 amino acids in total and having an average hydropathy index of −3.0 to −1.0 and [3] the hydrophobic amino acid block containing 20 to 32 amino acids in total, containing one or more His residues, and having an average hydropathy index of 1.0 to 2.5.
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