THE PRESENT INVENTION RELATES TO AN IMMUNOGENIC FUSION PROTEIN WHICH COMPRISES AT LEAST, ON THE C-TERMINAL SIDE, A FIRST PEPTIDE COMPOSED OF THE S PROTEIN DELETED OF THE TRANSMEMBRANE DOMAIN THEREOF LOCATED AT THE N-TERMINAL END THEREOF, OF A HEPATITIS B VIRUS (HBV) ISOLATE, AND ON THE N-TERMINAL SIDE, A SECOND PEPTIDE COMPOSED OF THE TRANSMEMBRANE DOMAIN AND OF THE ECTODOMAIN OF AT LEAST ONE ENVELOPE PROTEIN OF A HEPATITIS C VIRUS (HCV) ISOLATE. THE SUBJECT MATTER OF THE INVENTION IS ALSO A HYBRID NUCLEIC ACID MOLECULE ENCODING SAID FUSION PROTEIN, AND ALSO A VECTOR COMPRISING SAID HYBRID NUCLEIC ACID MOLECULE, A SUBVIRAL PARTICLE COMPRISING SAID FUSION PROTEIN, AN IMMUNOGENIC COMPOSITION COMPRISING AT LEAST SAID FUSION PROTEIN, OR AT LEAST SAID HYBRID NUCLEIC ACID MOLECULE, OR AT LEAST SAID SUBVIRAL PARTICLE, AND A CELL LINE FOR THE PRODUCTION OF SAID FUSION PROTEIN, OR OF SAID HYBRID NUCLEIC ACID MOLECULE, OR OF SAID SUBVIRAL PARTICLE.
