A compound of formula (I), or a pharmaceutically acceptable salt, hydrate, complex or prodrug thereof, wherein one of R 1 and R 2 is H, and the other is selected from C 1-8 -alkyl, C 3-6 -cycloalkyl and C 1-8 -alkyl-C 5-10 -aryl； R 3 is selected from tert -butylmethyl, iso-propylmethyl, sec- butyl, tert-butyl, cyclopentyl, cyclohexyl and 1-methylcyclopentyl； R 9 is selected from the following: wherein: R 4 is selected from C 1-8 -alkyl and C 3-8 -cycloalkyl； G is selected from: CH, CMe and N； E is selected from: O, S, SO 2 , NH, NMe and N-oxide； J and R are indepen70dently selected from: CH, N and N-oxide； and R 41 is selected from amino, methylamino, dimethylamino, isopropylamino, isopropyl(methyl)amino, cyclopropylamino, cyclopropyl(methyl)amino, cyclopentylamino, morpholino, piperidin-1-yl, piperidin-1-ylmethyl, morpholinomethyl, 4-methylpiperazin-1-yl, 4-(2-methoxyethyl)piperazin-1-yl, 1-morpholinoethyl, 1-(dimethylamino)ethyl, 1-(methylamino)ethyl, 4-fluoro-1-methylpyrrolidin-2-yl, 4,4-difluoropiperidin-1-yl, piperidin-4-yl, 1-memylpiperidin-4-yl, pyridin-3-ylamino, pyridin-2-ylamino, 1-methylpyrrolidin-3-yl, methyl, isopropyl. The invention further relates to pharmaceutical compositions comprising compounds of formula (I), and the use of such compounds in the treatment of various diseases.
