Methods for producing recombinant factor VIII chains from non-filamentous fungi, their functional reconstitution and applications thereof

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专利权人:

CENTRE FOR BIOSEPARATION TECHNOLOGY-VIT;Christian Medical College

发明人:

Vijayalakshmi Mookambeswaran Arunachalam,Vignesh Narasimhan Janakiraman,Krishnan Venkataraman,Sudheer Reddy Aswatha Reddy,Satheeshkumar Padikkara Kutty,Sukesh Chandran Nair,Alok Srivastava

申请号：

US14427622

公开号：

US09708387B2

申请日:

2013.09.11

申请国别(地区):

US

年份:

2017

代理人:

摘要：

A process of producing heavy chain peptide and/or light chain peptide of recombinant Factor VIII protein includes using the Pichia pastoris expression system. A process of producing a functional recombinant Factor VIII protein by reconstituting the Heavy chain and Light chain produced using said Pichia pastoris expression system. The said functional recombinant Factor VIII protein shows improved activity and therefore is used in the management of haemophilia.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/