Song Wang,Darin M. Taverna,Carl Di Casoli,Nicholas Willumsen,Morten Karsdal,Thomas Mueller
申请号：
US16413559
公开号：
US20190351031A1
申请日:
2019.05.15
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Provided herein are methods of selecting subjects having cancer for combination therapy that includes administering an anti-hyaluronan agent, such as a polymer-conjugated hyaluronan-degrading enzyme. Combination therapies can include, in addition to the anti-hyaluronan agent, a tumor-targeted taxane and, optionally, a chemotherapeutic agent such as a nucleoside analog. Combinations for performing the methods are provided, as are uses of the combinations for selecting subjects for treatment. The combination therapy can be used in methods of treating cancers, and in particular solid tumor cancers.
