Kyowa Hakko Kirin Co., Limited;La Jolla Institute for Allergy and Immunology
发明人:
Steven W. Granger,Shinichiro Kato,Carl F. Ware
申请号：
US13889608
公开号：
US08974787B2
申请日:
2013.05.08
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Provided herein are antibodies that immunospecifically bind to an hLIGHT polypeptide； isolated nucleic acids encoding the antibodies； vectors and host cells comprising nucleic acids encoding the antibodies； methods of making the antibodies； and a method of treating a hLIGHT-mediated disease in a subject comprising administering to the subject the antibodies. In preferred embodiments, the anti-hLIGHT antibodies provided herein will ameliorate, neutralize or otherwise inhibit hLIGHT biological activity in vivo (e.g., the hLIGHT-mediated production or secretion of CCL20, IL-8 or RANTES from a cell expressing a hLIGHT receptor). Also provided herein is a method for the detection of hLIGHT in a sample as well as a method for ameliorating, neutralizing or otherwise inhibiting hLIGHT activity, e.g., in a human subject suffering from a disorder in which hLIGHT activity is detrimental.
